Event Title

ESBL (Extended Spectrum Beta Lactamase) Infections - an Emerging Problem in Children

Session

Medical, Chemical and Pharmaceutical Sciences

Description

There is an emergence of infections with ESBL-producing micro-organisms recently. They remain poorly characterized in children. We sought to characterize children in a teaching hospital from whom an ESBL-producing organism had been isolated. We identified all children under sixteen years of age who had ESBL-producing organism isolated in the year 2016 in children admitted to pediatric hospital at University Hospital center “Mother Theresa”, Tirana. The referral source was contacted for further information where possible. Clinical details and treatment were analyzed to determine likelihood of infection or colonization. Fifteen children were identified, aged three months to nine years. Thirteen isolates were obtained from urine, one each from a wound swab and a cough swab. Three isolates were obtained from hospitalized children, but only one of these needed treatment. This child presented with lymphadenitis and continued to be pyrexial and irritable despite treatment with cephalosporin. Subsequently ESBL producing organism was isolated from the urine and she responded to appropriate antibiotic. Data was available for nine out of twelve patients originating from the community. Of these, four had repeat specimens which didn't grow ESBL-producer again. Three were treated and two remained asymptomatic and well. ESBL-producing organisms are increasingly isolated in children, but from our review appear frequently to be colonizers rather than pathogens. However, it is very important to be vigilant about the possibility of ESBL infection in children especially if they fail standard antibiotic therapy.

Keywords:

beta lactamase, wound

Session Chair

Besnik Elshani

Session Co-Chair

Petrit Biberaj

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-437-54-7

Location

Durres, Albania

Start Date

28-10-2017 2:00 PM

End Date

28-10-2017 3:30 PM

DOI

10.33107/ubt-ic.2017.301

This document is currently not available here.

Share

COinS
 
Oct 28th, 2:00 PM Oct 28th, 3:30 PM

ESBL (Extended Spectrum Beta Lactamase) Infections - an Emerging Problem in Children

Durres, Albania

There is an emergence of infections with ESBL-producing micro-organisms recently. They remain poorly characterized in children. We sought to characterize children in a teaching hospital from whom an ESBL-producing organism had been isolated. We identified all children under sixteen years of age who had ESBL-producing organism isolated in the year 2016 in children admitted to pediatric hospital at University Hospital center “Mother Theresa”, Tirana. The referral source was contacted for further information where possible. Clinical details and treatment were analyzed to determine likelihood of infection or colonization. Fifteen children were identified, aged three months to nine years. Thirteen isolates were obtained from urine, one each from a wound swab and a cough swab. Three isolates were obtained from hospitalized children, but only one of these needed treatment. This child presented with lymphadenitis and continued to be pyrexial and irritable despite treatment with cephalosporin. Subsequently ESBL producing organism was isolated from the urine and she responded to appropriate antibiotic. Data was available for nine out of twelve patients originating from the community. Of these, four had repeat specimens which didn't grow ESBL-producer again. Three were treated and two remained asymptomatic and well. ESBL-producing organisms are increasingly isolated in children, but from our review appear frequently to be colonizers rather than pathogens. However, it is very important to be vigilant about the possibility of ESBL infection in children especially if they fail standard antibiotic therapy.