Event Title

The Effect of Low-Level Laser Therapy on the Level of Il-2 as an Adjunct to Non-Surgical Periodontal Treatment of Patients with T2dm

Session

Medical, Dental and Pharmaceutical Sciences

Description

The aim of the study was to investigate the effect oflow- level laser therapy (LLLT)on IL-2 values in the gingival crevicularfluid (GCF),among patients with type 2 diabetes mellitus (T2DM) and periodontitis, at different time intervals. 80 subjects in total with type 2 diabetes mellitus and chronicalperiodontitis, withdetermined CAL (clinical attachment loss) of ≥4 mm of at least 50% of the affected teeth, enrolled the study. Based on the received treatment, subjects were distributed in two groups,whether they were treated with conservative periodontal treatment with an adjunctive LLLT (group A) and with conservative periodontal treatment only (group B). The adjunctiveLLLT, with performance (660 nm, 10mW, 8 min / day, in contact with the gingiva); was performed five days continuously, with 4 minutes of duration. Patientsfrom the group B (n=40) were treated only with conservative periodontal treatment. In all subjects was determined IL-2 from samples of from at least 10 periodontal pockets (≥4 mm), at three time intervals: at the first examination, six weeks later and three months after the treatment. The values of IL-2 were systematically and continuously reduced in the A group andat the first examination were between 12.29 ± 0.63 pg / 30s, after 6 weeks values were 10.38 ±0.55 pg / 30s, and after 3 months 9.76 ± 1.72 pg / 30 s. In Group Bthe values of IL- 2 were reduced moderately, but were higher than in the Group A. The value of IL-2 in GCF after 6 weeks and 3 months of therapy in group B is significantly higher in relation to the value in patients in group A.The difference in IL-2 values indicates lower values of this biomarker in Group A relative to group B. Differences in values between the two groups resulted in statistically significantly lower values of IL-2in the group with an adjunct low- level laser therapy that indicates that LLLT has an important role over this pro-inflammatory biomarker.

Keywords:

Periodontitis, type 2 of diabetes mellitus, Interleukin 2, Gingival crevicular fluid, low-level laser therapy

Session Chair

Agim Prokshaj

Session Co-Chair

Aida Rexhepi

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-437-69-1

Location

Pristina, Kosovo

Start Date

27-10-2018 10:45 AM

End Date

27-10-2018 12:15 PM

DOI

10.33107/ubt-ic.2018.378

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Oct 27th, 10:45 AM Oct 27th, 12:15 PM

The Effect of Low-Level Laser Therapy on the Level of Il-2 as an Adjunct to Non-Surgical Periodontal Treatment of Patients with T2dm

Pristina, Kosovo

The aim of the study was to investigate the effect oflow- level laser therapy (LLLT)on IL-2 values in the gingival crevicularfluid (GCF),among patients with type 2 diabetes mellitus (T2DM) and periodontitis, at different time intervals. 80 subjects in total with type 2 diabetes mellitus and chronicalperiodontitis, withdetermined CAL (clinical attachment loss) of ≥4 mm of at least 50% of the affected teeth, enrolled the study. Based on the received treatment, subjects were distributed in two groups,whether they were treated with conservative periodontal treatment with an adjunctive LLLT (group A) and with conservative periodontal treatment only (group B). The adjunctiveLLLT, with performance (660 nm, 10mW, 8 min / day, in contact with the gingiva); was performed five days continuously, with 4 minutes of duration. Patientsfrom the group B (n=40) were treated only with conservative periodontal treatment. In all subjects was determined IL-2 from samples of from at least 10 periodontal pockets (≥4 mm), at three time intervals: at the first examination, six weeks later and three months after the treatment. The values of IL-2 were systematically and continuously reduced in the A group andat the first examination were between 12.29 ± 0.63 pg / 30s, after 6 weeks values were 10.38 ±0.55 pg / 30s, and after 3 months 9.76 ± 1.72 pg / 30 s. In Group Bthe values of IL- 2 were reduced moderately, but were higher than in the Group A. The value of IL-2 in GCF after 6 weeks and 3 months of therapy in group B is significantly higher in relation to the value in patients in group A.The difference in IL-2 values indicates lower values of this biomarker in Group A relative to group B. Differences in values between the two groups resulted in statistically significantly lower values of IL-2in the group with an adjunct low- level laser therapy that indicates that LLLT has an important role over this pro-inflammatory biomarker.