Synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde
Session
Pharmaceutical and Natural Sciences
Description
Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family. The aims of this study were the synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde.
The Claisen-Schmidt condensation was used for the synthesis of chalcone derivatives but the conventional Claisen-Schmidt condensation procedure for the synthesis of substituted chalcones was occasionally modified.
The obtained syntheses were analyzed by measuring the melting points, recrystallizing them, performing chromatography and recording the IR spectra. Melting point values ranged from 101.6 ºC to 244.6 ºC, while the retention factor values ranged from 0.37 to 0.93. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OH, -OCH3, C-Cl and C-Br.
The results obtained from this study showed that the obtained chalcones are the required chalcones.
Keywords:
chalcone, flavonoid, 4-nitrobenzaldehyde, Claisen-Schmidt conden-sation.
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-47-5
First Page
1
Location
UBT Kampus, Lipjan
Start Date
30-10-2021 12:00 AM
End Date
30-10-2021 12:00 AM
DOI
10.33107/ubt-ic.2021.92
Recommended Citation
Rifati-Nixha, Arleta; Halili, Teuta; and Sopjani, Miribane Dërmaku, "Synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde" (2021). UBT International Conference. 158.
https://knowledgecenter.ubt-uni.net/conference/2021UBTIC/all-events/158
Synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde
UBT Kampus, Lipjan
Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family. The aims of this study were the synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde.
The Claisen-Schmidt condensation was used for the synthesis of chalcone derivatives but the conventional Claisen-Schmidt condensation procedure for the synthesis of substituted chalcones was occasionally modified.
The obtained syntheses were analyzed by measuring the melting points, recrystallizing them, performing chromatography and recording the IR spectra. Melting point values ranged from 101.6 ºC to 244.6 ºC, while the retention factor values ranged from 0.37 to 0.93. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OH, -OCH3, C-Cl and C-Br.
The results obtained from this study showed that the obtained chalcones are the required chalcones.