Event Title

Synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde

Session

Pharmaceutical and Natural Sciences

Description

Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family. The aims of this study were the synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde.

The Claisen-Schmidt condensation was used for the synthesis of chalcone derivatives but the conventional Claisen-Schmidt condensation procedure for the synthesis of substituted chalcones was occasionally modified.

The obtained syntheses were analyzed by measuring the melting points, recrystallizing them, performing chromatography and recording the IR spectra. Melting point values ranged from 101.6 ºC to 244.6 ºC, while the retention factor values ranged from 0.37 to 0.93. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OH, -OCH3, C-Cl and C-Br.

The results obtained from this study showed that the obtained chalcones are the required chalcones.

Keywords:

chalcone, flavonoid, 4-nitrobenzaldehyde, Claisen-Schmidt conden-sation.

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-550-47-5

First Page

1

Location

UBT Kampus, Lipjan

Start Date

30-10-2021 12:00 AM

End Date

30-10-2021 12:00 AM

DOI

10.33107/ubt-ic.2021.92

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Oct 30th, 12:00 AM Oct 30th, 12:00 AM

Synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde

UBT Kampus, Lipjan

Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family. The aims of this study were the synthesis and structural characterization of some new substituted chalcone derivatives starting from 4-nitrobenzaldehyde.

The Claisen-Schmidt condensation was used for the synthesis of chalcone derivatives but the conventional Claisen-Schmidt condensation procedure for the synthesis of substituted chalcones was occasionally modified.

The obtained syntheses were analyzed by measuring the melting points, recrystallizing them, performing chromatography and recording the IR spectra. Melting point values ranged from 101.6 ºC to 244.6 ºC, while the retention factor values ranged from 0.37 to 0.93. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OH, -OCH3, C-Cl and C-Br.

The results obtained from this study showed that the obtained chalcones are the required chalcones.