Event Title

Left ventricular function in children with Coarctation of the Aorta

Session

Medicine and Nursing

Description

Surgical repair of coarctation of the aorta (CoA) is a safe procedure in children, however the condition is known for its potential recurrence and other related complications. The available evidence shows abnormal intrinsic properties of the aorta in CoA, thus suggesting additional effect, even after CoA repair, on left ventricular (LV) function. Accordingly, we sought to obtain a better understanding of LV myocardial mechanics in very early-corrected CoA using two-dimensional STE.

Methods and results: We retrospectively studied 21 patients with corrected CoA at a median age of 9 (2–53) days at three time points: 1) just before intervention, 2) at short-term follow-up (within 3 months after intervention) and 3) at medium-term follow-up after intervention (median 2.3 years) and compared them with normal values. Speckle tracking analysis was conducted via vendor independent software, Tomtec. After intervention, LV function significantly improved (from −12.8 ± 3.9 to −16.7 ± 1.7; p < 0.001), however normal values were not reached even at medium-term follow-up (−18.3 ± 1.7 vs. −20 ± 1.6; p = 0.002). Medium-term longitudinal strain correlated with pre intervention EF (r = 0.58, p = 0.006). Moreover, medium-term subnormal values were more frequently associated with bicuspid aortic valve (33.3% vs. 66.6%; p < 0.05).

Conclusion: LV myocardial function in neonates with CoA can be feasibly evaluated and followed up by speckle tracking echocardiography. LV subendocardial dysfunction however, remains in early infancy coarctation long after repair. Long-term follow-up through adulthood using myocardial deformation measurements should shed light on the natural history and consequences of this anomaly.

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-550-47-5

Location

UBT Kampus, Lipjan

Start Date

30-10-2021 12:00 AM

End Date

30-10-2021 12:00 AM

DOI

10.33107/ubt-ic.2021.209

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Oct 30th, 12:00 AM Oct 30th, 12:00 AM

Left ventricular function in children with Coarctation of the Aorta

UBT Kampus, Lipjan

Surgical repair of coarctation of the aorta (CoA) is a safe procedure in children, however the condition is known for its potential recurrence and other related complications. The available evidence shows abnormal intrinsic properties of the aorta in CoA, thus suggesting additional effect, even after CoA repair, on left ventricular (LV) function. Accordingly, we sought to obtain a better understanding of LV myocardial mechanics in very early-corrected CoA using two-dimensional STE.

Methods and results: We retrospectively studied 21 patients with corrected CoA at a median age of 9 (2–53) days at three time points: 1) just before intervention, 2) at short-term follow-up (within 3 months after intervention) and 3) at medium-term follow-up after intervention (median 2.3 years) and compared them with normal values. Speckle tracking analysis was conducted via vendor independent software, Tomtec. After intervention, LV function significantly improved (from −12.8 ± 3.9 to −16.7 ± 1.7; p < 0.001), however normal values were not reached even at medium-term follow-up (−18.3 ± 1.7 vs. −20 ± 1.6; p = 0.002). Medium-term longitudinal strain correlated with pre intervention EF (r = 0.58, p = 0.006). Moreover, medium-term subnormal values were more frequently associated with bicuspid aortic valve (33.3% vs. 66.6%; p < 0.05).

Conclusion: LV myocardial function in neonates with CoA can be feasibly evaluated and followed up by speckle tracking echocardiography. LV subendocardial dysfunction however, remains in early infancy coarctation long after repair. Long-term follow-up through adulthood using myocardial deformation measurements should shed light on the natural history and consequences of this anomaly.