Session

Medical, Chemical and Pharmaceutical Sciences

Description

Aspirin is among the most commonly used pharmaceutical products used for the management of fever, to relieve mild to moderate pain, to reduce swelling in inflammatory conditions such as arthritis, while a low dose aspirin is used to prevent blood clots. The latter effect reduces the risk of stroke and heart attack. However, its use is associated with gastrointestinal and other complications. The aim of this study was to evaluate the influence of aspirin in bleeding ulcers. 122 patients were included in this prospective comparative study that were divided in two groups: the first group consisting of 60 patients that were treated with low dose Aspirin, and the second group consisting of 62 patients that were treated with low dose aspirin and pantoprazole (a proton pump inhibitor). All the patients had positive history for previous ulcer disease in whom bleeding ulcers were evaluated with endoscopic examinations during 12 months of treatment. The mean age of the patients with bleeding ulcers in the study was 60.4±14.3 years, of whom 68.8% were males and 31.2 % were females. In the aspirin only treated group, after 12 months of administration, bleeding ulcers were present in 11 patients (18.3 %) while in the group that were co-prescribed aspirin and pantoprazole were present only in 3 (4.8 %) patients. Findings from this study show that the prevalence of bleeding ulcers is significantly higher in the group treated with aspirin as monotherapy compared to the group that were co-prescribed aspirin and pantoprazole. Gastroprotection with proton pump inhibitors is essential in patients with positive history of gastrointestinal ulcers in the past that need long-term use of prophylactic low-dose aspirin.

Keywords:

bleeding ulcers, aspirin, PPI

Session Chair

Besnik Elshani

Session Co-Chair

Petrit Biberaj

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-437-67-7

First Page

62

Last Page

66

Location

Durres, Albania

Start Date

28-10-2017 11:00 AM

End Date

28-10-2017 12:30 PM

DOI

10.33107/ubt-ic.2017.292

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Oct 28th, 11:00 AM Oct 28th, 12:30 PM

Bleeding Ulcers: Effect of low dose Aspirin - Our experience

Durres, Albania

Aspirin is among the most commonly used pharmaceutical products used for the management of fever, to relieve mild to moderate pain, to reduce swelling in inflammatory conditions such as arthritis, while a low dose aspirin is used to prevent blood clots. The latter effect reduces the risk of stroke and heart attack. However, its use is associated with gastrointestinal and other complications. The aim of this study was to evaluate the influence of aspirin in bleeding ulcers. 122 patients were included in this prospective comparative study that were divided in two groups: the first group consisting of 60 patients that were treated with low dose Aspirin, and the second group consisting of 62 patients that were treated with low dose aspirin and pantoprazole (a proton pump inhibitor). All the patients had positive history for previous ulcer disease in whom bleeding ulcers were evaluated with endoscopic examinations during 12 months of treatment. The mean age of the patients with bleeding ulcers in the study was 60.4±14.3 years, of whom 68.8% were males and 31.2 % were females. In the aspirin only treated group, after 12 months of administration, bleeding ulcers were present in 11 patients (18.3 %) while in the group that were co-prescribed aspirin and pantoprazole were present only in 3 (4.8 %) patients. Findings from this study show that the prevalence of bleeding ulcers is significantly higher in the group treated with aspirin as monotherapy compared to the group that were co-prescribed aspirin and pantoprazole. Gastroprotection with proton pump inhibitors is essential in patients with positive history of gastrointestinal ulcers in the past that need long-term use of prophylactic low-dose aspirin.