Acromegaly and its Treatment
Session
Medical, Chemical and Pharmaceutical Sciences
Description
Acromegaly is a hormonal disorder which results when pituitary adenoma produces more growth hormone (GH). The most common symptoms of acromegaly are: severe face, thickening of soft tissues such as the face, typical hands like "shovels", jaw is more forward (Prognathism), sweating, impaired glucose tolerance or diabetes mellitus. The treatment focuses on lowering GH production, as well as reducing the negative effects of the tumor in the pituitary gland and surrounding tissues. Doctors can remove the pituitary tumor by using a method called transfenoid surgery with radiation. The medicines used to reduce the production or block the action of GH include: Somatostatin analogs, dopamine agonists, GH antagonists: Pegvisomant or Somavert, an analog of human growth hormone (GH) which is structurally modified to act as an antagonist GH receptor. Pegvisomant is a recombinant DNA protein containing 191 amino acid residues. Pegvisomant is synthesized by a specific origin of Escherichia Coli bacteria, which has been genetically modified by the addition of a plasmid that carries a gene for the antagonists of GH receptor. Somavert is available in a single dose, sterile bottle containing 10, 15, or 20 mg of pegvisomant protein. Each bottle also contains 1.36 mg glycine, 36.0 mg manitol, 1.04 mg sodium phosphate anhydrous, and 0.36 mg phosphate sodium monohydrate miono-basic. Get emergency medical help if you have any signs of an allergic reaction. Do not use pegvisomant if you have a serious side effect.
Keywords:
Acromegaly, pegvisomant
Session Chair
Arianit Jakupi
Session Co-Chair
Valon Ejupi
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-437-54-7
Location
Durres, Albania
Start Date
28-10-2017 9:00 AM
End Date
28-10-2017 10:30 AM
DOI
10.33107/ubt-ic.2017.294
Recommended Citation
Krasniqi, Dafina and Elshani, Florentina, "Acromegaly and its Treatment" (2017). UBT International Conference. 294.
https://knowledgecenter.ubt-uni.net/conference/2017/all-events/294
Acromegaly and its Treatment
Durres, Albania
Acromegaly is a hormonal disorder which results when pituitary adenoma produces more growth hormone (GH). The most common symptoms of acromegaly are: severe face, thickening of soft tissues such as the face, typical hands like "shovels", jaw is more forward (Prognathism), sweating, impaired glucose tolerance or diabetes mellitus. The treatment focuses on lowering GH production, as well as reducing the negative effects of the tumor in the pituitary gland and surrounding tissues. Doctors can remove the pituitary tumor by using a method called transfenoid surgery with radiation. The medicines used to reduce the production or block the action of GH include: Somatostatin analogs, dopamine agonists, GH antagonists: Pegvisomant or Somavert, an analog of human growth hormone (GH) which is structurally modified to act as an antagonist GH receptor. Pegvisomant is a recombinant DNA protein containing 191 amino acid residues. Pegvisomant is synthesized by a specific origin of Escherichia Coli bacteria, which has been genetically modified by the addition of a plasmid that carries a gene for the antagonists of GH receptor. Somavert is available in a single dose, sterile bottle containing 10, 15, or 20 mg of pegvisomant protein. Each bottle also contains 1.36 mg glycine, 36.0 mg manitol, 1.04 mg sodium phosphate anhydrous, and 0.36 mg phosphate sodium monohydrate miono-basic. Get emergency medical help if you have any signs of an allergic reaction. Do not use pegvisomant if you have a serious side effect.