Chalcone synthesis, properties and medicinal applications
Session
Pharmaceutical and Natural Sciences
Description
Chalcones belong to the flavonoids family which constitutes one of the main classes of heterocyclic compounds found in nature. The aim of this study is the synthesis and structural characterization of some new substituted 1,3-diphenyl-2-propen-1-one derivatives. We have synthesized a series of simple chalcones derivatives through the Claisen-Schmidt condensation method, briefly, we have explained the methods and catalysts used in the synthesis of chalcones. The synthesized compounds are characterized by several analyzes, recrystallizing them, measuring melting points, by thin layer chromatography and recording of IR spectra. Melting point values ranged from 105.35ºC to 156ºC, while retention factor values ranged from 0.8 to 0.95. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OCH3, C-Cl. The results obtained from this study showed that the chalcones obtained are the chalcones required.
Keywords:
chalcone, flavonoid, 1, 3-diphenyl-2-propen-1-one, thin layer chroma- tography, Claisen-Schmidt condensation.
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-47-5
First Page
1
Location
UBT Kampus, Lipjan
Start Date
30-10-2021 12:00 AM
End Date
30-10-2021 12:00 AM
DOI
10.33107/ubt-ic.2021.81
Recommended Citation
Rifati-Nixha, Arleta; Miftari, Elsa; and Sopjani, Miribane Dërmaku, "Chalcone synthesis, properties and medicinal applications" (2021). UBT International Conference. 148.
https://knowledgecenter.ubt-uni.net/conference/2021UBTIC/all-events/148
Chalcone synthesis, properties and medicinal applications
UBT Kampus, Lipjan
Chalcones belong to the flavonoids family which constitutes one of the main classes of heterocyclic compounds found in nature. The aim of this study is the synthesis and structural characterization of some new substituted 1,3-diphenyl-2-propen-1-one derivatives. We have synthesized a series of simple chalcones derivatives through the Claisen-Schmidt condensation method, briefly, we have explained the methods and catalysts used in the synthesis of chalcones. The synthesized compounds are characterized by several analyzes, recrystallizing them, measuring melting points, by thin layer chromatography and recording of IR spectra. Melting point values ranged from 105.35ºC to 156ºC, while retention factor values ranged from 0.8 to 0.95. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OCH3, C-Cl. The results obtained from this study showed that the chalcones obtained are the chalcones required.