Event Title

Chalcone synthesis, properties and medicinal applications

Session

Pharmaceutical and Natural Sciences

Description

Chalcones belong to the flavonoids family which constitutes one of the main classes of heterocyclic compounds found in nature. The aim of this study is the synthesis and structural characterization of some new substituted 1,3-diphenyl-2-propen-1-one derivatives. We have synthesized a series of simple chalcones derivatives through the Claisen-Schmidt condensation method, briefly, we have explained the methods and catalysts used in the synthesis of chalcones. The synthesized compounds are characterized by several analyzes, recrystallizing them, measuring melting points, by thin layer chromatography and recording of IR spectra. Melting point values ranged from 105.35ºC to 156ºC, while retention factor values ranged from 0.8 to 0.95. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OCH3, C-Cl. The results obtained from this study showed that the chalcones obtained are the chalcones required.

Keywords:

chalcone, flavonoid, 1, 3-diphenyl-2-propen-1-one, thin layer chroma- tography, Claisen-Schmidt condensation.

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-550-47-5

First Page

1

Location

UBT Kampus, Lipjan

Start Date

30-10-2021 12:00 AM

End Date

30-10-2021 12:00 AM

DOI

10.33107/ubt-ic.2021.81

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Oct 30th, 12:00 AM Oct 30th, 12:00 AM

Chalcone synthesis, properties and medicinal applications

UBT Kampus, Lipjan

Chalcones belong to the flavonoids family which constitutes one of the main classes of heterocyclic compounds found in nature. The aim of this study is the synthesis and structural characterization of some new substituted 1,3-diphenyl-2-propen-1-one derivatives. We have synthesized a series of simple chalcones derivatives through the Claisen-Schmidt condensation method, briefly, we have explained the methods and catalysts used in the synthesis of chalcones. The synthesized compounds are characterized by several analyzes, recrystallizing them, measuring melting points, by thin layer chromatography and recording of IR spectra. Melting point values ranged from 105.35ºC to 156ºC, while retention factor values ranged from 0.8 to 0.95. By interpreting the IR spectra we have confirmed the presence of functional groups, for example the groups -NO2, -OCH3, C-Cl. The results obtained from this study showed that the chalcones obtained are the chalcones required.