Helicobacter pylori and its treatment
Session
Medicine and Nursing
Description
Background. H. pylori infection is a common worldwide infection that is an important cause of gastritis, peptic ulcer disease, MALT lymphoma and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-inflammatory medication, unexplained iron deficiency anemia, and idiopathic thrombocytopenic purpura.
Methods. While choosing a treatment regimen for H. pylori, patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process. For first-line treatment, clarithromycin triple therapy should be confined to patients with noprevious history of macrolide exposure who reside in areas where clarithromycin resistance amongst H. pylori isolates is known to be low.
Results. Most patients will be better served by first-line treatment with bismuth quadruple therapy orconcomitant therapy consisting of a PPI, clarithromycin, amoxicillin, and metronidazole. When first-line therapy fails, a salvage regimen should avoid antibiotics that were previously used.
Conclusions. If a patient received a first-line treatment containing clarithromycin, bismuth quadruple therapy or levofloxacin salvage regimens are the preferred treatment options. If a patient received first-line bismuth quadriple therapy, clarithromycin or levofloxacin-containing salvage regimens are the preferred treatment options. Details regarding the drugs, doses and durations of the recommended and suggested first-line and salvage regimens can be found in the current guideline.
Keywords:
helicobacter pylori, infection, treatment.
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-50-5
Location
UBT Kampus, Lipjan
Start Date
29-10-2022 12:00 AM
End Date
30-10-2022 12:00 AM
DOI
10.33107/ubt-ic.2022.176
Recommended Citation
Gashi, Zaim, "Helicobacter pylori and its treatment" (2022). UBT International Conference. 178.
https://knowledgecenter.ubt-uni.net/conference/2022/all-events/178
Helicobacter pylori and its treatment
UBT Kampus, Lipjan
Background. H. pylori infection is a common worldwide infection that is an important cause of gastritis, peptic ulcer disease, MALT lymphoma and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-inflammatory medication, unexplained iron deficiency anemia, and idiopathic thrombocytopenic purpura.
Methods. While choosing a treatment regimen for H. pylori, patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process. For first-line treatment, clarithromycin triple therapy should be confined to patients with noprevious history of macrolide exposure who reside in areas where clarithromycin resistance amongst H. pylori isolates is known to be low.
Results. Most patients will be better served by first-line treatment with bismuth quadruple therapy orconcomitant therapy consisting of a PPI, clarithromycin, amoxicillin, and metronidazole. When first-line therapy fails, a salvage regimen should avoid antibiotics that were previously used.
Conclusions. If a patient received a first-line treatment containing clarithromycin, bismuth quadruple therapy or levofloxacin salvage regimens are the preferred treatment options. If a patient received first-line bismuth quadriple therapy, clarithromycin or levofloxacin-containing salvage regimens are the preferred treatment options. Details regarding the drugs, doses and durations of the recommended and suggested first-line and salvage regimens can be found in the current guideline.