A case of anti-VGKC antibody encephalitis
Session
Medicine and Nursing
Description
Limbic encephalitis is, as the name itself says, inflammation of limbic system and other parts of brain and of a larger group of the autoimmune disorders. Its main characteristic or symptom, is sever affection of the short or working memory. Other symptoms are confusion, psychiatric symptomatology and seizures.Usually the pathophysiologic process is initiated by a paraneoplastic one in making (Limbic paraneoplasticEncephalitis), but this sometime may not be the case ( Limbic Non-paraneoplastic Encephalitis).
Case Presentation
This a case presentation of a 60 years old woman, which is hospitalized in Neurologic Clinic in UCC, Prishtina, because of the seizures, occurring in sleep. After a week severe confusion begins, together with memory loss and then, within a day, generalized epileptic seizures. Also the patient develops marked hyponatremia. The case is diagnosed as Limbic Encephalitis based on clinical picture, imagery (MRI) andspecific antibody testing , with VGKC antibody positive titer that is against potassium channels.
Conclusion
Limbic Encephalitis is very challenging; the discrepancy between the clinical symptoms, encephalopathy, specific antibody titers and limited treatment options makes this diagnosis especially difficult in every aspect of the disease. The pathophysiologic changes associated with this disease remain unclear.
Keywords:
Limbic Encephalitis, VGKC potassium channel voltage regulated channels, hyponatremia, autoimmune epilepsy, MRI.
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-50-5
Location
UBT Kampus, Lipjan
Start Date
29-10-2022 12:00 AM
End Date
30-10-2022 12:00 AM
DOI
10.33107/ubt-ic.2022.187
Recommended Citation
Pushka, Melihate and Alidema, Arieta Hasani, "A case of anti-VGKC antibody encephalitis" (2022). UBT International Conference. 189.
https://knowledgecenter.ubt-uni.net/conference/2022/all-events/189
A case of anti-VGKC antibody encephalitis
UBT Kampus, Lipjan
Limbic encephalitis is, as the name itself says, inflammation of limbic system and other parts of brain and of a larger group of the autoimmune disorders. Its main characteristic or symptom, is sever affection of the short or working memory. Other symptoms are confusion, psychiatric symptomatology and seizures.Usually the pathophysiologic process is initiated by a paraneoplastic one in making (Limbic paraneoplasticEncephalitis), but this sometime may not be the case ( Limbic Non-paraneoplastic Encephalitis).
Case Presentation
This a case presentation of a 60 years old woman, which is hospitalized in Neurologic Clinic in UCC, Prishtina, because of the seizures, occurring in sleep. After a week severe confusion begins, together with memory loss and then, within a day, generalized epileptic seizures. Also the patient develops marked hyponatremia. The case is diagnosed as Limbic Encephalitis based on clinical picture, imagery (MRI) andspecific antibody testing , with VGKC antibody positive titer that is against potassium channels.
Conclusion
Limbic Encephalitis is very challenging; the discrepancy between the clinical symptoms, encephalopathy, specific antibody titers and limited treatment options makes this diagnosis especially difficult in every aspect of the disease. The pathophysiologic changes associated with this disease remain unclear.