The influence of systemic drugs affecting the process of osseointegration of dental implants
Session
Dental Sciences
Description
The process of osteointegration of dental implants is a biological process in which systemic therapy can interfere, which affects the anabolic and catabolic processes of the bone and consequently leads to the failure of the implant.
The purpose of the literature review has to do with certain groups of systemic drugs that have a direct impact on this process.
Some of the systemic drugs that have a direct impact on the osteointegration processes of dental implants are:
selective serotonin reuptake inhibitors, bisphosphonates, non-steroidal anti-inflammatory drugs, proton pump inhibitors, glucocorticoid drug.
SSRIs - cause bone loss by inhibiting bone remodeling processes.
Bisphosphonates - associated osteonecrosis occurs after dental implant surgery.
Non-Steroidal anti-inflammatory drugs - Non-steroidal anti-inflammatory drugs and their impact before implant placement has to do with the inhibition of cyclooxygenase COX-enzymes and consequently inhibits the inflammatory mediators Prostaglandins, which play the main role in bone metabolism.
Proton pump inhibitors- negatively affect the process of osteointegration of dental implants in such a way that they affect the absorption of Calcium as well as the activity of osteoclast.
Glucocorticoid drug- Increasing the humane serum levels of glucocorticoids in vitro to supraphysiological doses decreases the ability of osteoblasts to differentiate.
Keywords:
Osteointegration; Bisphosphonates; Drug related; Non-steroidal anti-inflammatory drug; SSRIs, Proton pump inhibitors, Dental failure.
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-50-5
Location
UBT Kampus, Lipjan
Start Date
29-10-2022 12:00 AM
End Date
30-10-2022 12:00 AM
DOI
10.33107/ubt-ic.2022.233
Recommended Citation
Fazliu, Vullnet and Rizaj, Aferdita, "The influence of systemic drugs affecting the process of osseointegration of dental implants" (2022). UBT International Conference. 238.
https://knowledgecenter.ubt-uni.net/conference/2022/all-events/238
The influence of systemic drugs affecting the process of osseointegration of dental implants
UBT Kampus, Lipjan
The process of osteointegration of dental implants is a biological process in which systemic therapy can interfere, which affects the anabolic and catabolic processes of the bone and consequently leads to the failure of the implant.
The purpose of the literature review has to do with certain groups of systemic drugs that have a direct impact on this process.
Some of the systemic drugs that have a direct impact on the osteointegration processes of dental implants are:
selective serotonin reuptake inhibitors, bisphosphonates, non-steroidal anti-inflammatory drugs, proton pump inhibitors, glucocorticoid drug.
SSRIs - cause bone loss by inhibiting bone remodeling processes.
Bisphosphonates - associated osteonecrosis occurs after dental implant surgery.
Non-Steroidal anti-inflammatory drugs - Non-steroidal anti-inflammatory drugs and their impact before implant placement has to do with the inhibition of cyclooxygenase COX-enzymes and consequently inhibits the inflammatory mediators Prostaglandins, which play the main role in bone metabolism.
Proton pump inhibitors- negatively affect the process of osteointegration of dental implants in such a way that they affect the absorption of Calcium as well as the activity of osteoclast.
Glucocorticoid drug- Increasing the humane serum levels of glucocorticoids in vitro to supraphysiological doses decreases the ability of osteoblasts to differentiate.