The influence of systemic drugs affecting the process of osseointegration of dental implants

Session

Dental Sciences

Description

The process of osteointegration of dental implants is a biological process in which systemic therapy can interfere, which affects the anabolic and catabolic processes of the bone and consequently leads to the failure of the implant.

The purpose of the literature review has to do with certain groups of systemic drugs that have a direct impact on this process.

Some of the systemic drugs that have a direct impact on the osteointegration processes of dental implants are:

selective serotonin reuptake inhibitors, bisphosphonates, non-steroidal anti-inflammatory drugs, proton pump inhibitors, glucocorticoid drug.

SSRIs - cause bone loss by inhibiting bone remodeling processes.

Bisphosphonates - associated osteonecrosis occurs after dental implant surgery.

Non-Steroidal anti-inflammatory drugs - Non-steroidal anti-inflammatory drugs and their impact before implant placement has to do with the inhibition of cyclooxygenase COX-enzymes and consequently inhibits the inflammatory mediators Prostaglandins, which play the main role in bone metabolism.

Proton pump inhibitors- negatively affect the process of osteointegration of dental implants in such a way that they affect the absorption of Calcium as well as the activity of osteoclast.

Glucocorticoid drug- Increasing the humane serum levels of glucocorticoids in vitro to supraphysiological doses decreases the ability of osteoblasts to differentiate.

Keywords:

Osteointegration; Bisphosphonates; Drug related; Non-steroidal anti-inflammatory drug; SSRIs, Proton pump inhibitors, Dental failure.

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-550-50-5

Location

UBT Kampus, Lipjan

Start Date

29-10-2022 12:00 AM

End Date

30-10-2022 12:00 AM

DOI

10.33107/ubt-ic.2022.233

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The influence of systemic drugs affecting the process of osseointegration of dental implants

UBT Kampus, Lipjan

The process of osteointegration of dental implants is a biological process in which systemic therapy can interfere, which affects the anabolic and catabolic processes of the bone and consequently leads to the failure of the implant.

The purpose of the literature review has to do with certain groups of systemic drugs that have a direct impact on this process.

Some of the systemic drugs that have a direct impact on the osteointegration processes of dental implants are:

selective serotonin reuptake inhibitors, bisphosphonates, non-steroidal anti-inflammatory drugs, proton pump inhibitors, glucocorticoid drug.

SSRIs - cause bone loss by inhibiting bone remodeling processes.

Bisphosphonates - associated osteonecrosis occurs after dental implant surgery.

Non-Steroidal anti-inflammatory drugs - Non-steroidal anti-inflammatory drugs and their impact before implant placement has to do with the inhibition of cyclooxygenase COX-enzymes and consequently inhibits the inflammatory mediators Prostaglandins, which play the main role in bone metabolism.

Proton pump inhibitors- negatively affect the process of osteointegration of dental implants in such a way that they affect the absorption of Calcium as well as the activity of osteoclast.

Glucocorticoid drug- Increasing the humane serum levels of glucocorticoids in vitro to supraphysiological doses decreases the ability of osteoblasts to differentiate.