OXIDATIVE STRESS EFFECT IN RIBOSOMAL BIOGENESIS IN CANCER CELLS
Session
Pharmaceutical and Natural Sciences
Description
Oxidative stress is a condition where the levels of reactive oxygen species (ROS) exceed the normal level on the cell’s antioxidant defenses. Oxidative stress can cause damage of the DNA, proteins, and lipids. Ribosome biogenesis is the process of making ribosomes. Ribosome biogenesis involves the transcription, processing, and assembly of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins) into functional ribosomal subunits. Cancer is a disease characterized by uncontrolled cell growth, invasion, and metastasis. Cancer cells often have increased levels of oxidative stress and ribosome biogenesis, which can promote their survival, adaptation, and proliferation in the tumor microenvironment. In this review, we discuss how oxidative stress can have different effects on ribosome biogenesis in cancer cells, depending on the type, severity, and duration of the stress, as well as the genetic and epigenetic characteristics of the cells.
Keywords:
oxidative stress, Ribosome biogenesis, acute lymphoblastic leukaemia, Therapy
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-95-6
Location
UBT Lipjan, Kosovo
Start Date
28-10-2023 8:00 AM
End Date
29-10-2023 6:00 PM
DOI
10.33107/ubt-ic.2023.113
Recommended Citation
Ejupi, Gazmend, "OXIDATIVE STRESS EFFECT IN RIBOSOMAL BIOGENESIS IN CANCER CELLS" (2023). UBT International Conference. 7.
https://knowledgecenter.ubt-uni.net/conference/IC/PNS/7
OXIDATIVE STRESS EFFECT IN RIBOSOMAL BIOGENESIS IN CANCER CELLS
UBT Lipjan, Kosovo
Oxidative stress is a condition where the levels of reactive oxygen species (ROS) exceed the normal level on the cell’s antioxidant defenses. Oxidative stress can cause damage of the DNA, proteins, and lipids. Ribosome biogenesis is the process of making ribosomes. Ribosome biogenesis involves the transcription, processing, and assembly of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins) into functional ribosomal subunits. Cancer is a disease characterized by uncontrolled cell growth, invasion, and metastasis. Cancer cells often have increased levels of oxidative stress and ribosome biogenesis, which can promote their survival, adaptation, and proliferation in the tumor microenvironment. In this review, we discuss how oxidative stress can have different effects on ribosome biogenesis in cancer cells, depending on the type, severity, and duration of the stress, as well as the genetic and epigenetic characteristics of the cells.