Session

Pharmaceutical and Natural Sciences

Description

Oxidative stress is a condition where the levels of reactive oxygen species (ROS) exceed the normal level on the cell’s antioxidant defenses. Oxidative stress can cause damage of the DNA, proteins, and lipids. Ribosome biogenesis is the process of making ribosomes. Ribosome biogenesis involves the transcription, processing, and assembly of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins) into functional ribosomal subunits. Cancer is a disease characterized by uncontrolled cell growth, invasion, and metastasis. Cancer cells often have increased levels of oxidative stress and ribosome biogenesis, which can promote their survival, adaptation, and proliferation in the tumor microenvironment. In this review, we discuss how oxidative stress can have different effects on ribosome biogenesis in cancer cells, depending on the type, severity, and duration of the stress, as well as the genetic and epigenetic characteristics of the cells.

Keywords:

oxidative stress, Ribosome biogenesis, acute lymphoblastic leukaemia, Therapy

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-550-95-6

Location

UBT Lipjan, Kosovo

Start Date

28-10-2023 8:00 AM

End Date

29-10-2023 6:00 PM

DOI

10.33107/ubt-ic.2023.113

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Oct 28th, 8:00 AM Oct 29th, 6:00 PM

OXIDATIVE STRESS EFFECT IN RIBOSOMAL BIOGENESIS IN CANCER CELLS

UBT Lipjan, Kosovo

Oxidative stress is a condition where the levels of reactive oxygen species (ROS) exceed the normal level on the cell’s antioxidant defenses. Oxidative stress can cause damage of the DNA, proteins, and lipids. Ribosome biogenesis is the process of making ribosomes. Ribosome biogenesis involves the transcription, processing, and assembly of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins) into functional ribosomal subunits. Cancer is a disease characterized by uncontrolled cell growth, invasion, and metastasis. Cancer cells often have increased levels of oxidative stress and ribosome biogenesis, which can promote their survival, adaptation, and proliferation in the tumor microenvironment. In this review, we discuss how oxidative stress can have different effects on ribosome biogenesis in cancer cells, depending on the type, severity, and duration of the stress, as well as the genetic and epigenetic characteristics of the cells.