CORRELATION BETWEEN PARATHYROID ADENOMA AND OSTEOPOROSIS AT YOUNG PATIENT USING PARATHYROID SCINTIGRAPHY WITH TC99M MIBI RADIOPHARMACEUTICAL (CASE REPORT)
Session
Pharmaceutical and Natural Sciences
Description
Nuclear medicine parathyroid scintigraphy imaging, is an important method in the identification of hyperfunctioning parathyroid glands in primary hyperparathyroidism (pHPT), but it may be also valuable before surgical treatment in secondary hyperparathyroidism (sHPT). Parathyroid radionuclide imaging with scintigraphy is a highly sensitive procedure for the assessment of the presence and number of hyperfunctioning parathyroid glands, located either at typical sites or ectopically. Osteoporosis is a bone disease that develops when bone mineral density and bone mass decreases, or when the structure and strength of bone changes. This can lead to a decrease in bone strength that can increase the risk of fractures (broken bones).At young patient the osteoporosis is rare but with early detection and diagnosing of the parathyroid adenoma with Tc99 MIBI we may prevent the bone fractures and will improve the osteoporosis treatment. A male patient 32 years old reported at our department -Nuclear Medicne Departmend – UCC Prishtina with generalized pain in the skeleton. He first reported in our department for bone scan.The whole body scan show multiple foci that suggested for metabolic bone disease. After 6 six month was done parathyroid scintigraphy which revealed parathyroid adenoma confirmed by biopsy. Nuclear medicine parathyroid scintigraphy imaging, is an important method in the identification of hyperfunctioning parathyroid glands in primary hyperparathyroidism (pHPT), but it may be also valuable before surgical treatment in secondary hyperparathyroidism (sHPT). Parathyroid radionuclide imaging with scintigraphy is a highly sensitive procedure for the assessment of the presence and number of hyperfunctioning parathyroid glands, located either at typical sites or ectopically. Osteoporosis is a bone disease that develops when bone mineral density and bone mass decreases, or when the structure and strength of bone changes. This can lead to a decrease in bone strength that can increase the risk of fractures (broken bones).At young patient the osteoporosis is rare but with early detection and diagnosing of the parathyroid adenoma with Tc99 MIBI we may prevent the bone fractures and will improve the osteoporosis treatment. A male patient 32 years old reported at our department -Nuclear Medicne Departmend – UCC Prishtina with generalized pain in the skeleton. He first reported in our department for bone scan.The whole body scan show multiple foci that suggested for metabolic bone disease. After 6 six month was done parathyroid scintigraphy which revealed parathyroid adenoma confirmed by biopsy. The study objective is to assess the sensitivity and specificity of Tc99m-MIBI as a radiopharmaceutical and the parathyroid scintigraphy as a diagnostic tool for identification of parathyroid adenoma. The study was performed in the Department fNuclear Medicine Prishtina Equipment Gamma Camera. Sterile sodium pertechnetate (99m TcOFresh sterile sodium pertechnetate (99m Tc) solution for injection without oxidant eluate of 99Mo/99mTc radionuclide generator up to 2000 MBq( generator 16-20 Gbq, Monrol Turkey.99Mo/99mTc generator and 99mTcO4- from company. The molybdenum-technetium generator system is based on the principle that the shorter-lived radioactive daughter nuclide (99mTc –T1/2-6 h) can be easily and repeatedly isolated from its longer-lived parent radionuclide (99Mo-). Because of the high sensitivity and specificity of 99mTc-MIBI scintigraphy, routine preoperative localization is becoming a standard practice. In the assessment of patients with recurrent or persistent hyperparathyroidism, localization procedures prior to re-exploration are mandatory in order to prevent the osteoporosis and other effects of untreated parathyroid adenoma.
Keywords:
Tc99m-MIBI, radiopharmaceutical, diagnostic tool, sensitivity, scintigraphy
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-95-6
Location
UBT Lipjan, Kosovo
Start Date
28-10-2023 8:00 AM
End Date
29-10-2023 6:00 PM
DOI
10.33107/ubt-ic.2023.115
Recommended Citation
Bajrami, Ismet; Spahiu, Fakir; Kaçiu, Ylli; Drakalska, Elena; and Jashari, Armend, "CORRELATION BETWEEN PARATHYROID ADENOMA AND OSTEOPOROSIS AT YOUNG PATIENT USING PARATHYROID SCINTIGRAPHY WITH TC99M MIBI RADIOPHARMACEUTICAL (CASE REPORT)" (2023). UBT International Conference. 9.
https://knowledgecenter.ubt-uni.net/conference/IC/PNS/9
CORRELATION BETWEEN PARATHYROID ADENOMA AND OSTEOPOROSIS AT YOUNG PATIENT USING PARATHYROID SCINTIGRAPHY WITH TC99M MIBI RADIOPHARMACEUTICAL (CASE REPORT)
UBT Lipjan, Kosovo
Nuclear medicine parathyroid scintigraphy imaging, is an important method in the identification of hyperfunctioning parathyroid glands in primary hyperparathyroidism (pHPT), but it may be also valuable before surgical treatment in secondary hyperparathyroidism (sHPT). Parathyroid radionuclide imaging with scintigraphy is a highly sensitive procedure for the assessment of the presence and number of hyperfunctioning parathyroid glands, located either at typical sites or ectopically. Osteoporosis is a bone disease that develops when bone mineral density and bone mass decreases, or when the structure and strength of bone changes. This can lead to a decrease in bone strength that can increase the risk of fractures (broken bones).At young patient the osteoporosis is rare but with early detection and diagnosing of the parathyroid adenoma with Tc99 MIBI we may prevent the bone fractures and will improve the osteoporosis treatment. A male patient 32 years old reported at our department -Nuclear Medicne Departmend – UCC Prishtina with generalized pain in the skeleton. He first reported in our department for bone scan.The whole body scan show multiple foci that suggested for metabolic bone disease. After 6 six month was done parathyroid scintigraphy which revealed parathyroid adenoma confirmed by biopsy. Nuclear medicine parathyroid scintigraphy imaging, is an important method in the identification of hyperfunctioning parathyroid glands in primary hyperparathyroidism (pHPT), but it may be also valuable before surgical treatment in secondary hyperparathyroidism (sHPT). Parathyroid radionuclide imaging with scintigraphy is a highly sensitive procedure for the assessment of the presence and number of hyperfunctioning parathyroid glands, located either at typical sites or ectopically. Osteoporosis is a bone disease that develops when bone mineral density and bone mass decreases, or when the structure and strength of bone changes. This can lead to a decrease in bone strength that can increase the risk of fractures (broken bones).At young patient the osteoporosis is rare but with early detection and diagnosing of the parathyroid adenoma with Tc99 MIBI we may prevent the bone fractures and will improve the osteoporosis treatment. A male patient 32 years old reported at our department -Nuclear Medicne Departmend – UCC Prishtina with generalized pain in the skeleton. He first reported in our department for bone scan.The whole body scan show multiple foci that suggested for metabolic bone disease. After 6 six month was done parathyroid scintigraphy which revealed parathyroid adenoma confirmed by biopsy. The study objective is to assess the sensitivity and specificity of Tc99m-MIBI as a radiopharmaceutical and the parathyroid scintigraphy as a diagnostic tool for identification of parathyroid adenoma. The study was performed in the Department fNuclear Medicine Prishtina Equipment Gamma Camera. Sterile sodium pertechnetate (99m TcOFresh sterile sodium pertechnetate (99m Tc) solution for injection without oxidant eluate of 99Mo/99mTc radionuclide generator up to 2000 MBq( generator 16-20 Gbq, Monrol Turkey.99Mo/99mTc generator and 99mTcO4- from company. The molybdenum-technetium generator system is based on the principle that the shorter-lived radioactive daughter nuclide (99mTc –T1/2-6 h) can be easily and repeatedly isolated from its longer-lived parent radionuclide (99Mo-). Because of the high sensitivity and specificity of 99mTc-MIBI scintigraphy, routine preoperative localization is becoming a standard practice. In the assessment of patients with recurrent or persistent hyperparathyroidism, localization procedures prior to re-exploration are mandatory in order to prevent the osteoporosis and other effects of untreated parathyroid adenoma.