Synthesis and Characterization of Some new Chalcone Derivatives
Session
Medical, Dental and Pharmaceutical Sciences
Description
Chalcone is a generic term given to compounds bearing the 1,3-diphenyl-2-propen-1-one framework and belong to the flavonoid family. Chemically they are openchain flavonoids in which the two aromatic rings are joined by a three carbonα,β-unsaturated carbonyl system. Chalcones and its derivatives have attracted increasing attention due to numerous pharmacological applications. They have displayed a broad spectrum of pharmacological activities, among which antimalarial, anticancer, antiprotozoal (antileishmanial and antitrypanosomal), anti-inflammatory, antibacterial, antifilarial, antifungal, antimicrobial, larvicidal, anticonvulsant, antioxidant activities have been reported. 3-(2,5-dimethoxy-phenyl)-1-(4-methoxy-phenyl)-propenone, 3-(3,4-dichloro-phenyl)-1-(3-nitro-phenyl)-propenone, 3–(2-bromo-phenyl)-1-(3-nitro-phenyl)-propenone and 3-(3-bromo-phenyl)-1-(3-nitro-phenyl)-propenone (3a-d) were prepared by base catalyzed condensation of a mixture of the substituted acetophenones and substituted benzaldehydes in alcohol, 40% solution of potassium hydroxide (KOH) was added dropwise with stirring. The reaction mixture was kept at room temperature for 20-24 h, then diluted with water and acidified with 10% hydrochloric acid. The identity and structure of this compound was proven on the basis of spectral data and elemental microanalysis: 1HNMR, 13CNMR dhe IR
Keywords:
Chalcone, Flavonoid, Acetophenone, Benzaldehyde, Condensation
Session Chair
Shpend Dragusha
Session Co-Chair
Valon Ejupi
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-437-69-1
Location
Pristina, Kosovo
Start Date
27-10-2018 3:15 PM
End Date
27-10-2018 4:45 PM
DOI
10.33107/ubt-ic.2018.377
Recommended Citation
Përzhaku, Enver; Kastrati, Kaltrina; Isrefi, Qëndresa; Krasniqi, Fatjone; Krasniqi, Rina; and Rifati-Nixha, Arleta, "Synthesis and Characterization of Some new Chalcone Derivatives" (2018). UBT International Conference. 377.
https://knowledgecenter.ubt-uni.net/conference/2018/all-events/377
Synthesis and Characterization of Some new Chalcone Derivatives
Pristina, Kosovo
Chalcone is a generic term given to compounds bearing the 1,3-diphenyl-2-propen-1-one framework and belong to the flavonoid family. Chemically they are openchain flavonoids in which the two aromatic rings are joined by a three carbonα,β-unsaturated carbonyl system. Chalcones and its derivatives have attracted increasing attention due to numerous pharmacological applications. They have displayed a broad spectrum of pharmacological activities, among which antimalarial, anticancer, antiprotozoal (antileishmanial and antitrypanosomal), anti-inflammatory, antibacterial, antifilarial, antifungal, antimicrobial, larvicidal, anticonvulsant, antioxidant activities have been reported. 3-(2,5-dimethoxy-phenyl)-1-(4-methoxy-phenyl)-propenone, 3-(3,4-dichloro-phenyl)-1-(3-nitro-phenyl)-propenone, 3–(2-bromo-phenyl)-1-(3-nitro-phenyl)-propenone and 3-(3-bromo-phenyl)-1-(3-nitro-phenyl)-propenone (3a-d) were prepared by base catalyzed condensation of a mixture of the substituted acetophenones and substituted benzaldehydes in alcohol, 40% solution of potassium hydroxide (KOH) was added dropwise with stirring. The reaction mixture was kept at room temperature for 20-24 h, then diluted with water and acidified with 10% hydrochloric acid. The identity and structure of this compound was proven on the basis of spectral data and elemental microanalysis: 1HNMR, 13CNMR dhe IR