Uromodulin and chronic tubulointerstitial kidney disease
Session
Medicine and Nursing
Description
Uromodulin is a glycoprotein which is synthesized in nephron distal tubule epithelial cells.The purpose of this research is to determine the role of uromoduline in the pathogenesis of kidney damage in chronic tubulointerstitial diseases.Of the 101cases with chronic tubulointerstitial disease,48 cases were obstructive pyelonephritis and 53 cases nonobstructive pyelonephritis with vesicoureteral reflux.Uromodulin in the form of interstitial kidney deposition was found in a total of 26 cases(25.7%) of chronic obstructive and nonobstructive tubulointerstitial diseases.Of 26 cases with this interstitial protein,15 cases (58%) were obstructive pyelonephritis,while 11 cases (42%) were non obstructive pyelonephritis.In the largest number of cases with this PAS-positive protein,calcifications were found in the renal interstitium (21 of 26 cases or 81%),whereas in cases with PAS-negative protein these calcifications were found much less (19 of 75 cases or 25%).This difference with x2 test is significant.The largest number of cases with interstitial protein deposition was found in the kidneys with severe injury (16 of 26 cases or 61.5%),while in the kidneys with mild injury only in (3 of 26 cases or 11.5%).Around this protein in the kidney interstitium,lymphoplasmacytic infiltrates and macrophages are observed as an inflammatory reaction to uromodulin.This data indicate that uromodulin plays an important role in the pathogenesis of kidney damage in chronic ,especially obstructive tubulointerstitial diseases.
Keywords:
Chronic tubulointerstitias diseases, Uromodulin.
Session Chair
Syheda Latifi Hoxha
Session Co-Chair
Shqiptar Demaçi
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-19-2
Location
Pristina, Kosovo
Start Date
26-10-2019 3:30 PM
End Date
26-10-2019 5:00 PM
DOI
10.33107/ubt-ic.2019.314
Recommended Citation
Kamberaj, Xhevat, "Uromodulin and chronic tubulointerstitial kidney disease" (2019). UBT International Conference. 314.
https://knowledgecenter.ubt-uni.net/conference/2019/events/314
Uromodulin and chronic tubulointerstitial kidney disease
Pristina, Kosovo
Uromodulin is a glycoprotein which is synthesized in nephron distal tubule epithelial cells.The purpose of this research is to determine the role of uromoduline in the pathogenesis of kidney damage in chronic tubulointerstitial diseases.Of the 101cases with chronic tubulointerstitial disease,48 cases were obstructive pyelonephritis and 53 cases nonobstructive pyelonephritis with vesicoureteral reflux.Uromodulin in the form of interstitial kidney deposition was found in a total of 26 cases(25.7%) of chronic obstructive and nonobstructive tubulointerstitial diseases.Of 26 cases with this interstitial protein,15 cases (58%) were obstructive pyelonephritis,while 11 cases (42%) were non obstructive pyelonephritis.In the largest number of cases with this PAS-positive protein,calcifications were found in the renal interstitium (21 of 26 cases or 81%),whereas in cases with PAS-negative protein these calcifications were found much less (19 of 75 cases or 25%).This difference with x2 test is significant.The largest number of cases with interstitial protein deposition was found in the kidneys with severe injury (16 of 26 cases or 61.5%),while in the kidneys with mild injury only in (3 of 26 cases or 11.5%).Around this protein in the kidney interstitium,lymphoplasmacytic infiltrates and macrophages are observed as an inflammatory reaction to uromodulin.This data indicate that uromodulin plays an important role in the pathogenesis of kidney damage in chronic ,especially obstructive tubulointerstitial diseases.