Effects of chemotherapy and value of microscopic changes in lymphocytesof circulating bloodonpatients with oral cancer treated with chemotherapy
Session
Medicine and Nursing
Description
The value of micronucleus (MN) and microscopic changes in lymphocytes of circulating blood presents a good case to study changes of genome directly into organs affected by tumourAim: The aim of this research is to analyse the level of induction of MN and the value of microscopic changes in binuclear lymphocytes of venous circulating blood on patients with oral cancer during treatment with chemotherapy.Material and methodology: The study analyses 21 patients with oral carcinoma (72.2% male) with an average age of 54.7+-9.2. From parameters, we have analysed theeffect of the chemotherapy and microscopic changes in lymphocytes of the circulating blood of patients diagnosed with oral cancer. Results:Changes of degenerations of microscopic cells at patients with oral malign processes in lymphocytes of circulating bloodwere noticed, as after chemotherapy there are significant changes (16.7±27.2 vs. 27.8±33.6, p<0.0001).Also we have defined a significant change regarding all apoptic binuclear lymphocytes (p<0.00001), necrotic lymphocytes (p<0.0002), and lymphocytes with nucleoplasmbridge. Conclusion:Results show that chemotherapeutics have induced cytotoxity of cells but have not induced chromosomal changes or formation of micronucleus formation.
Keywords:
micronucleus, oral cancers, chemotherapy
Session Chair
Besnik Elshani
Session Co-Chair
Valdete Serreqi
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-437-96-7
Location
Lipjan, Kosovo
Start Date
31-10-2020 10:45 AM
End Date
31-10-2020 12:15 PM
DOI
10.33107/ubt-ic.2020.411
Recommended Citation
Alidema, Fitim; Alidema, Arieta Hasani; Alidema, Mirzade; and Alidema, Flakron, "Effects of chemotherapy and value of microscopic changes in lymphocytesof circulating bloodonpatients with oral cancer treated with chemotherapy" (2020). UBT International Conference. 414.
https://knowledgecenter.ubt-uni.net/conference/2020/all_events/414
Effects of chemotherapy and value of microscopic changes in lymphocytesof circulating bloodonpatients with oral cancer treated with chemotherapy
Lipjan, Kosovo
The value of micronucleus (MN) and microscopic changes in lymphocytes of circulating blood presents a good case to study changes of genome directly into organs affected by tumourAim: The aim of this research is to analyse the level of induction of MN and the value of microscopic changes in binuclear lymphocytes of venous circulating blood on patients with oral cancer during treatment with chemotherapy.Material and methodology: The study analyses 21 patients with oral carcinoma (72.2% male) with an average age of 54.7+-9.2. From parameters, we have analysed theeffect of the chemotherapy and microscopic changes in lymphocytes of the circulating blood of patients diagnosed with oral cancer. Results:Changes of degenerations of microscopic cells at patients with oral malign processes in lymphocytes of circulating bloodwere noticed, as after chemotherapy there are significant changes (16.7±27.2 vs. 27.8±33.6, p<0.0001).Also we have defined a significant change regarding all apoptic binuclear lymphocytes (p<0.00001), necrotic lymphocytes (p<0.0002), and lymphocytes with nucleoplasmbridge. Conclusion:Results show that chemotherapeutics have induced cytotoxity of cells but have not induced chromosomal changes or formation of micronucleus formation.