Effects of chemotherapy and value of microscopic changes in lymphocytesof circulating bloodonpatients with oral cancer treated with chemotherapy

Session

Medicine and Nursing

Description

The value of micronucleus (MN) and microscopic changes in lymphocytes of circulating blood presents a good case to study changes of genome directly into organs affected by tumourAim: The aim of this research is to analyse the level of induction of MN and the value of microscopic changes in binuclear lymphocytes of venous circulating blood on patients with oral cancer during treatment with chemotherapy.Material and methodology: The study analyses 21 patients with oral carcinoma (72.2% male) with an average age of 54.7+-9.2. From parameters, we have analysed theeffect of the chemotherapy and microscopic changes in lymphocytes of the circulating blood of patients diagnosed with oral cancer. Results:Changes of degenerations of microscopic cells at patients with oral malign processes in lymphocytes of circulating bloodwere noticed, as after chemotherapy there are significant changes (16.7±27.2 vs. 27.8±33.6, p<0.0001).Also we have defined a significant change regarding all apoptic binuclear lymphocytes (p<0.00001), necrotic lymphocytes (p<0.0002), and lymphocytes with nucleoplasmbridge. Conclusion:Results show that chemotherapeutics have induced cytotoxity of cells but have not induced chromosomal changes or formation of micronucleus formation.

Keywords:

micronucleus, oral cancers, chemotherapy

Session Chair

Besnik Elshani

Session Co-Chair

Valdete Serreqi

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-437-96-7

Location

Lipjan, Kosovo

Start Date

31-10-2020 10:45 AM

End Date

31-10-2020 12:15 PM

DOI

10.33107/ubt-ic.2020.411

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Oct 31st, 10:45 AM Oct 31st, 12:15 PM

Effects of chemotherapy and value of microscopic changes in lymphocytesof circulating bloodonpatients with oral cancer treated with chemotherapy

Lipjan, Kosovo

The value of micronucleus (MN) and microscopic changes in lymphocytes of circulating blood presents a good case to study changes of genome directly into organs affected by tumourAim: The aim of this research is to analyse the level of induction of MN and the value of microscopic changes in binuclear lymphocytes of venous circulating blood on patients with oral cancer during treatment with chemotherapy.Material and methodology: The study analyses 21 patients with oral carcinoma (72.2% male) with an average age of 54.7+-9.2. From parameters, we have analysed theeffect of the chemotherapy and microscopic changes in lymphocytes of the circulating blood of patients diagnosed with oral cancer. Results:Changes of degenerations of microscopic cells at patients with oral malign processes in lymphocytes of circulating bloodwere noticed, as after chemotherapy there are significant changes (16.7±27.2 vs. 27.8±33.6, p<0.0001).Also we have defined a significant change regarding all apoptic binuclear lymphocytes (p<0.00001), necrotic lymphocytes (p<0.0002), and lymphocytes with nucleoplasmbridge. Conclusion:Results show that chemotherapeutics have induced cytotoxity of cells but have not induced chromosomal changes or formation of micronucleus formation.