The ribosome modification! To modify or to die?
Session
Pharmaceutical and Natural Sciences
Description
Normal and malignant cell growth is determinate by the synthesis of rRNA. RNAs it is possibility chemically to modified in different ways. First is thought that this modification is static, but lastly is revealed that some modification it is possibility to be reversed. This reversed process it is possibility to play pivotal role in different cell biological processes in all three kingdoms of life. In eukaryotes exist different form of protein post-translational modifications (PTMs), including phosphorylation, poly(ADP-ribosyl)ation, ubiquitylation, pseudouridylation, sumoylation, methylation, acetylation and others, and in this form is regulate protein stability, localization and activity without the need for changes in de novo protein synthesis. The energy which is required for RNA modification also is very higher. Here we report form some modification such as SUMOylation and Methylation.
Keywords:
Methylation., Sumolyation, rRNA., tRNA., Ribosomal protein
Proceedings Editor
Edmond Hajrizi
ISBN
978-9951-550-50-5
Location
UBT Kampus, Lipjan
Start Date
29-10-2022 12:00 AM
End Date
30-9-2022 12:00 AM
DOI
10.33107/ubt-ic.2022.102
Recommended Citation
Nuhi, Nexhibe; Xheladini, Jehona; Shabani, Arjeta; Alija, Gjylai; Bilalli, Sefedin; and Temaj, Gazmend, "The ribosome modification! To modify or to die?" (2022). UBT International Conference. 102.
https://knowledgecenter.ubt-uni.net/conference/2022/all-events/102
The ribosome modification! To modify or to die?
UBT Kampus, Lipjan
Normal and malignant cell growth is determinate by the synthesis of rRNA. RNAs it is possibility chemically to modified in different ways. First is thought that this modification is static, but lastly is revealed that some modification it is possibility to be reversed. This reversed process it is possibility to play pivotal role in different cell biological processes in all three kingdoms of life. In eukaryotes exist different form of protein post-translational modifications (PTMs), including phosphorylation, poly(ADP-ribosyl)ation, ubiquitylation, pseudouridylation, sumoylation, methylation, acetylation and others, and in this form is regulate protein stability, localization and activity without the need for changes in de novo protein synthesis. The energy which is required for RNA modification also is very higher. Here we report form some modification such as SUMOylation and Methylation.