The rate of development of a primary malignant tumor based on the TNM classification. Depending on the clearly defined criteria, there are several levels of stages and sub-stages. Such a classification also applies when it comes to Breast Carcinoma. Case study

Skender Dreshaj

Session

Medicine and Nursing

Description

Stage IB of breast cancer with TNM classification as T0N1miM0 cases when it is not found with malignant changes of a primary tumor in the breast, but there is microstasis in a lymph node (usually in the armpit) and stage II A, when cells may not be found. malignant in the tissue of the gland but there are 1-3 lymph nodes attacked with diameter over 2 mm. These cases are not common.

The standard of the paper is to produce a discussion on the questions resulting from the case study and previously the findings from the results of the pathohistological analysis after bilateral total mastectomy with axillary lymphadenectomy and the course of the disease as evidenced by the documentation-history of the disease, with a special focus. according to the true nature of the palpated node in the right breast which, in the ultrasound examination, sometimes has a suspicious characteristic of malignancy. /9.7mm, 10/9/7 mm to disappear after 2 years with persistent suspicious lymph nodes).

The case study has two peculiarities:

In the histopathological examination of the breast gland after mastectomy, no cells with malignant changes are found, not even a single non-proliferative dysplastic change, metastatic malignant changes in only 1 lymph node 2 mm out of a total of 18 excised (IIA classification) Luminal B ( Er +, Her2 , Ke 67 -35%) , cases that are not common.

The peculiarity of the case, of the objects of the study, is the fact that at the beginning we had a self-palpated node by the patient and the suspects in the ultrasonography examination in the right breast, behind the areola, which has a suspicious lymph node in the right armpit. After two observation comments, the nodule in the breast recedes-disappears, while the lymph gland subjected to the first biopsy is a node with metastatic carcinoma originating in the breast gland, as well as after bilateral total subcutaneous mastectomy changes with resection of the axilla, the tissue found correctly. non-proliferative dysplastic and left proliferative dysplastic changes. Out of 18 lymph nodes dissected in the axilla, only one lymph node with malignant metastatic changes with high probability from the breast gland (immunohistochemical analysis).

The question that comes to my mind and became the driving force of the real study was whether the disappearance of the nodule in the gland could be the result and competent immunological responses of the older patient of the primary malignant process in the breast?!

Of course, based on the follow-up procedures during the diagnosis of the patients, the examinations at the beginning when the node was present, based only on the ultrasonographic examination, the malignant nature of the change can be documented.

Further results prove, unequivocally, the malignant nature of the lymph gland originating from the breast, since in the PH examination of the two breast glands (after mastectomy) the primary source is not found, in my opinion, it makes the question whether we have it legitimate from a theoretical point of view. do with can understand competent immune, so a functional immune system!

Determination of the level of Tumor Infiltrating Lymphocytes (TIL) if it was not important in value, taking into account the classification of the Luminal B subtype (WHO recommendation)?!

Through the chronological description of the history of the disease and the commentary on the analyses, diagnostic procedures, therapeutics and results, which is the methodology of punishment, I hope to justify the questions posed and thus this paper.

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-550-50-5

Location

UBT Kampus, Lipjan

Start Date

29-10-2022 12:00 AM

End Date

30-10-2022 12:00 AM

DOI

10.33107/ubt-ic.2022.162

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The rate of development of a primary malignant tumor based on the TNM classification. Depending on the clearly defined criteria, there are several levels of stages and sub-stages. Such a classification also applies when it comes to Breast Carcinoma. Case study

UBT Kampus, Lipjan

Stage IB of breast cancer with TNM classification as T0N1miM0 cases when it is not found with malignant changes of a primary tumor in the breast, but there is microstasis in a lymph node (usually in the armpit) and stage II A, when cells may not be found. malignant in the tissue of the gland but there are 1-3 lymph nodes attacked with diameter over 2 mm. These cases are not common.

The standard of the paper is to produce a discussion on the questions resulting from the case study and previously the findings from the results of the pathohistological analysis after bilateral total mastectomy with axillary lymphadenectomy and the course of the disease as evidenced by the documentation-history of the disease, with a special focus. according to the true nature of the palpated node in the right breast which, in the ultrasound examination, sometimes has a suspicious characteristic of malignancy. /9.7mm, 10/9/7 mm to disappear after 2 years with persistent suspicious lymph nodes).

The case study has two peculiarities:

In the histopathological examination of the breast gland after mastectomy, no cells with malignant changes are found, not even a single non-proliferative dysplastic change, metastatic malignant changes in only 1 lymph node 2 mm out of a total of 18 excised (IIA classification) Luminal B ( Er +, Her2 , Ke 67 -35%) , cases that are not common.

The peculiarity of the case, of the objects of the study, is the fact that at the beginning we had a self-palpated node by the patient and the suspects in the ultrasonography examination in the right breast, behind the areola, which has a suspicious lymph node in the right armpit. After two observation comments, the nodule in the breast recedes-disappears, while the lymph gland subjected to the first biopsy is a node with metastatic carcinoma originating in the breast gland, as well as after bilateral total subcutaneous mastectomy changes with resection of the axilla, the tissue found correctly. non-proliferative dysplastic and left proliferative dysplastic changes. Out of 18 lymph nodes dissected in the axilla, only one lymph node with malignant metastatic changes with high probability from the breast gland (immunohistochemical analysis).

The question that comes to my mind and became the driving force of the real study was whether the disappearance of the nodule in the gland could be the result and competent immunological responses of the older patient of the primary malignant process in the breast?!

Of course, based on the follow-up procedures during the diagnosis of the patients, the examinations at the beginning when the node was present, based only on the ultrasonographic examination, the malignant nature of the change can be documented.

Further results prove, unequivocally, the malignant nature of the lymph gland originating from the breast, since in the PH examination of the two breast glands (after mastectomy) the primary source is not found, in my opinion, it makes the question whether we have it legitimate from a theoretical point of view. do with can understand competent immune, so a functional immune system!

Determination of the level of Tumor Infiltrating Lymphocytes (TIL) if it was not important in value, taking into account the classification of the Luminal B subtype (WHO recommendation)?!

Through the chronological description of the history of the disease and the commentary on the analyses, diagnostic procedures, therapeutics and results, which is the methodology of punishment, I hope to justify the questions posed and thus this paper.