MicroRNAs and NRF2: Mastering the Balance of Cellular Defense in Breast Cancer and Unlocking New Therapeutic Pathways

Session

Pharmaceutical and Natural Sciences

Description

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a critical role in regulating gene expression, impacting various cellular processes in cancer development and progression. In breast cancer, one of the key molecular players involved in maintaining cellular defense mechanisms is Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). NRF2 is responsible for activating antioxidant responses, allowing cancer cells to survive under oxidative stress. However, aberrant NRF2 activation can lead to enhanced tumor growth, drug resistance, and metastasis. Breast cancer remains one of the most prevalent and deadly cancers worldwide, making it crucial to explore the molecular mechanisms driving its progression and treatment resistance in order to develop more effective, targeted therapies. This presentation will examine the complex interplay between microRNAs (miRNAs) and NRF2 in breast cancer. Specifically, the influence of miRNAs on NRF2 expression and activity will be discussed, along with how NRF2 regulates miRNA networks. Key miRNAs that promote or inhibit NRF2 signaling and their roles in cancer cell survival and treatment resistance will be highlighted. Additionally, novel therapeutic strategies targeting the miRNA-NRF2 axis will be explored to improve patient outcomes. Understanding these interactions may lead to more effective, personalized treatments for breast cancer.

Keywords:

Breast Cancer, MicroRNAs (miRNAs), NRF2 Pathway, Oxidative Stress, Therapeutic Resistance.

Proceedings Editor

Edmond Hajrizi

ISBN

978-9951-982-15-3

Location

UBT Kampus, Lipjan

Start Date

25-10-2024 9:00 AM

End Date

27-10-2024 6:00 PM

DOI

10.33107/ubt-ic.2024.162

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Oct 25th, 9:00 AM Oct 27th, 6:00 PM

MicroRNAs and NRF2: Mastering the Balance of Cellular Defense in Breast Cancer and Unlocking New Therapeutic Pathways

UBT Kampus, Lipjan

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a critical role in regulating gene expression, impacting various cellular processes in cancer development and progression. In breast cancer, one of the key molecular players involved in maintaining cellular defense mechanisms is Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). NRF2 is responsible for activating antioxidant responses, allowing cancer cells to survive under oxidative stress. However, aberrant NRF2 activation can lead to enhanced tumor growth, drug resistance, and metastasis. Breast cancer remains one of the most prevalent and deadly cancers worldwide, making it crucial to explore the molecular mechanisms driving its progression and treatment resistance in order to develop more effective, targeted therapies. This presentation will examine the complex interplay between microRNAs (miRNAs) and NRF2 in breast cancer. Specifically, the influence of miRNAs on NRF2 expression and activity will be discussed, along with how NRF2 regulates miRNA networks. Key miRNAs that promote or inhibit NRF2 signaling and their roles in cancer cell survival and treatment resistance will be highlighted. Additionally, novel therapeutic strategies targeting the miRNA-NRF2 axis will be explored to improve patient outcomes. Understanding these interactions may lead to more effective, personalized treatments for breast cancer.